Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism

Fig. 3

Co-housing with 6 M mice changed the intestinal metabolite composition and metabolic pathways of 2 M mice. a Principal components analysis (PCA) of fecal metabolites from Sep-2M Co-2M and 6 M mice. b Heatmap of metabolites identified in fecal samples. c Volcano plot of metabolites identified in fecal samples. Volcano plots are depicted with the fold change of each metabolite and the q value was calculated by performing a t-test and corrected by the false discovery rate. d, e Pathway enrich analysis of metabolites from Sep-2M and Sep-6M mice, and Sep-2M and Co-2M mice. f, g Relative abundance of linoleic acid and oleic acid in fecal metabolites. Data presented as mean ± SD on relevant graphs. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005 (one-way ANOVA). Sep-2M (n = 8), Co-2M (n = 8), and 6 M (n = 7)

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