Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism

Fig. 8

The administration of PDE-4 inhibitors significantly improved psoriasis-like skin phenotype in K14-VEGF mice and was accompanied by recovery of intestinal microbiota. a Macroscopic characteristics of the ears in Vehicle and PDE-4 inhibitor group mice in 0 week and 6 weeks. b Improvement percentages of PASI score of ears in Vehicle and PDE-4 inhibitor group mice from 0 week to 6 weeks. c Taxonomic distributions of bacteria. d PcoA of unweighted UniFrac distance based on 16s rDNA profiling of feces from Vehicle and PDE-4 inhibitor group mice. e, f Relative abundance of Parabacteroides distasonis and Prevotella in the feces of Vehicle and PDE-4 inhibitor group mice. Data presented as mean ± SD on relevant graphs. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005 (two-tailed Student’s t-test) (n = 3)

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