Fig. 4
From: Copper homeostasis and cuproptosis in health and disease
Two potential therapeutic strategies to target cuproptosis in cancer. a The Cu ionophore elesclomol is believed to induce cuproptosis in cancer cells that either express high levels of lipoylated mitochondrial enzymes or are in a hyperactive respiratory state. b Disulfiram combined with Cu selectively targets cancer cells with high ALDH expression. Created with BioRender. ALDH aldehyde dehydrogenase, DSF disulfiram
