Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

Fig. 7

SGM-miR146a-Exo@SFP attenuated inflammation and increased neovascularization of diabetic wounds. a–c Immunofluorescence of IRAK1, IL-6, and IB4 of the wound tissue (scale bar: 200 μm). d–f Statistical analyses of IRAK1, IL-6, and IB4 immunofluorescence. g The IRAK1 expression was decreased in SGM-miR146a-Exo@SFP group. h The IL-6 expression was decreased in SGM-miR146a-Exo@SFP group. i The increased CD31 expression in SGM-miR146a-Exo@SFP group. j The increased VEGF expression in SGM-miR146a-Exo@SFP group. Data represent the mean ± S.D. of three different experiments (ns: no significance, *p < 0.05, **p < 0.01, ***p < 0.001)

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