Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer

Fig. 5

RCT weakens the tumor-promoting features of cancer-associated fibroblasts. a UMAP visualization of 6 CAF subclusters in all (left panel), pre-RCT (middle panel), and post-RCT (right panel) samples. b Bar plots showing the relative proportions of 6 CAF subclusters pre- and post-RCT. c Box plots showing the fold change in the abundance of each CAF subcluster compared between pre- and post-RCT samples. The colors of dots and squares represent patients and sample groups, respectively. The p values correspond to paired Wilcoxon tests. d Heatmap showing the scaled expression level of signature genes in each CAF subcluster. e Violin plots showing the changes in the average expression of signature genesets in all CAFs between pre- and post-RCT groups (two-sided Wilcoxon test). f Heatmap showing the relative change in the expression level of signature genes in all CAFs and each CAF subcluster between pre- and post-RCT groups. The intensity of the color indicates the extent of upregulation in post-RCT (red) or pre-RCT (blue) samples. g GSVA analysis of hallmark pathways of CAFs in pre-RCT versus post-RCT samples

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