Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer

Fig. 6

RCT enhances angiogenic, hypoxic, and inflammatory features of endothelial cells. a UMAP visualization of 5 EC subclusters in all (left panel), pre-RCT (middle panel), and post-RCT samples (right panel). b GO term analyses of EC subclusters. c Bar plots showing the relative proportions of 5 EC subclusters in all EC in pre- and post-RCT samples. d Box plots showing the fold change in the abundance of each EC subcluster compared between pre- and post-RCT samples. The colors of dots and squares represent patients and sample groups, respectively. The p values correspond to paired Wilcoxon tests. e The enriched GO terms and KEGG pathways of ECs in pre-RCT versus post-RCT samples. f Violin plots showing the indicated pathway enrichment of EC2-4 cells between pre- and post-RCT groups (two-sided Wilcoxon test). g GSVA analysis of hallmark pathways of ECs in pre-RCT versus post-RCT samples

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