Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

Fig. 7

IMPDH2 expression and the nucleolar metabolism are significantly associated with responses to AVN-944 in KMT2Ar-AML. a, b Spearman rank correlation between response to AVN-944 and IMDH2 protein and mRNA expression. c Protein expression of IMPDH2 across MLLGA and MLLGB. d Distribution of Spearman rank correlation values between response (DSS) for AVN-944 and protein expression. e Term enrichment analysis in the sets of proteins significantly positively or negatively correlated in d. f Number of phosphopeptides significantly affected by 24 h treatment with 1 µM AVN-944 as a function of term linkage. Phosphopeptides were counted when p-value < 0.05 and fold change (log2) > 0.7 (positive values) or < −0.7 (negative values). g Selection of proteins significantly affected by treatment with 1 µM AVN-944 and linked to the nucleolus or the ribosome biology. Statistical significance was calculated using unpaired two-sided Student’s t-test (c, f, g). ****p ≤ 0.0001, ***p ≤ 0.001, **p ≤ 0.01 and *p ≤ 0.05 (c, g). FDR values obtained by the adjustment of p-values using the Benjamini-Hochberg procedure (c, d). Statistical difference was calculated using a modified Fisher’s exact test (d). In g, n = 4 biological replicates

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