Table 1 The major features of intratumoral microbiota
From: Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Tumor type | Bacterial compositions | Effect 1 | Ref. 1 | Fungal compositions | Effect 2 | Ref. 2 | ||
|---|---|---|---|---|---|---|---|---|
Intestinal cancer | E. coli | Initiation of cancers | DNA mutations | Saccharomycetales, S. cerevisiae, C. albicans | No results posted | |||
B. fragilis | ||||||||
C. jejuni | ||||||||
H. pylori | Activating carcinogenic pathways | |||||||
S. typhi | ||||||||
F. nucleatum | Promoting tumor progression | Promoting chronic inflammation | ||||||
P. gingivalis | ||||||||
Bifidobacterium | Enhancing antitumor immune response | STING signaling activation | ||||||
H. hepaticus | TLS production | |||||||
Fusobacterium | Decreasing antitumor immune response | Upregulation of ROS | ||||||
Methylobacterium | T cell inactivation | |||||||
Glioblastoma | Acinetobacter, N. macacae, E. cloacae | No results posted | C. parapsilosis, C. Sphaerospermum, M. globose | No results posted | ||||
Pancreatic ductal adenocarcinoma | E. asburiae, K. pneumonia, C. freundii | No results posted | Y. bubula | No results posted | ||||
P. gingivalis | Promoting tumor progression | Promoting chronic inflammation | Malassezia | Promoting tumor progression | Activation complement system | |||
Saccharopolyspora, Pseudoxanthomonas, Streptomyces | Enhancing antitumor immune response | T cell activation | ||||||
Melanoma | P. marcusii, S. aureus | No results posted | M. restricta, M. globose | No results posted | ||||
A. muciniphila | Enhancing antitumor immune response | STING signaling activation | ||||||
Lachnoclostridium | T cell activation | |||||||
Bifidobacterium | NK cell activation | |||||||
Lung cancer | Corynebacterium, L. iners, S. yunnanensis, P. marcusii, K. pneumonia, R. mucosa, N. macacae | No results posted | Capnodiales, C. sphaerospermum | No results posted | ||||
Breast cancer | S. infantis, L. iners, Corynebacterium, F. nucleatum, P. marcusii, S. cohnii, S. aureus, Acinetobacter | No results posted | M. arunalokei, M. restricta, M. globosa, Y. porcina, Aspergillus, A. penicillioides, Capnodiales, S. roseus | No results posted | ||||
Staphylococcus, Lactobacillus, Streptococcus | Promoting tumor progression | Initiating metastasis | ||||||
Clostridiales | Enhancing antitumor immune response | T cell activation | ||||||
Ovarian cancer | R. mucosa, Sphingomonas, S. cohnii | No results posted | A. clavatophorus, V.victoria, P. hubeiensis, P. juncicola, A. penicillioides | No results posted | ||||
Bone cancer | S. yanoikuyae, A. massiliensis, P. argentinensis, E. asburiae | No results posted | Alternaria, A. glabripes, C. parapsilosis, P. juncicola, P. hubeiensis | No results posted | ||||
