Table 2 Therapeutic strategies using microbiota as vectors for cancer therapy
From: Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Classification | Therapeutic strategy | Microbiota type | Tumor type | Effect | Ref |
|---|---|---|---|---|---|
Vector producing cytotoxic drugs | Incubated with radiolabeled antibody | Listeria | Pancreatic cancer | Decreased metastasis | |
Engineered with NO | E. coli | Breast cancer | Tumor regression | ||
Vector for gene delivery | Bacteria-based DNA delivery system | Listeria | Breast cancer | The potential for in vivo gene delivery and gene therapy of cancers | |
FASL expression | Salmonella | Breast and colon cancer, melanoma | Evident antitumor responses | ||
Cytotoxic Cp53 peptide expression | Salmonella | Cervical and breast cancer | Induced the killing of tumor cells |
