Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape

Fig. 1

Novel mechanism of melanoma HLA class II-driven immune escape. With the assistance of indirect antitumor CD4+ Treg cells presented by Antigen-presenting cells (APCs), and direct antitumor Treg cells (major tumor-reactive cells), HLA class II positive melanoma cells evade immune surveillance. In addition, Melanoma directly induced cytotoxic CD4+ T cells depletion through HLA class I, but not directly induced Treg production through HLA class I. The figure was generated on Biorender.com

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