Table 3 Regulation of lncRNA in metabolic disease
From: Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Diseases | Major regulator | Target gene | Effect | References |
|---|---|---|---|---|
T1D | lncRNA SRAs | miR-146b | ↑ | |
T2D | lncRNA MALAT1 | Nrf2, JNK, Akt, IRS-1 | ↓ | |
GDM | lncRNA HOTTIP | WNT7A | ↓ | |
DKD | lncRNA MALAT1 | LIN28A | ↑ | |
DR | lncRNA ZNF503-AS1 | TGF-β | ↑ | |
diabetic wound healing | lncH19 | p53, GDF15 | ↑ | |
Obesity | lncRNA RP11-142A22.4 | miR-587 | ↑ | |
Obesity | lnc13728 | ZBED3 | ↑ | |
Obesity | lncH19 | miR-30a | ↑ | |
Obesity | lncFR332443 | RUNX1, MAPK | ↓ | |
Obesity | lncRNA MIR99AHG | miR-29b-3p | ↑ | |
Obesity | lncRNA U90926 | PPARγ, PPARγ2 | ↓ | |
Obesity | lncRNA XIST | C/EBPα | ↓ | |
Obesity | FOXC2-AS1 | UCP1 | ↓ | |
NAFLD | LncRNA Gm15622 | miR-742-3p | ↑ | |
NAFLD | Hilnc | IGF2BP2 | ↑ | |
NAFLD | lncRNA MALAT1 | CXCL5 | ↑ | |
NAFLD | lncRNA NEAT1 | miR-122 | ↑ | |
NAFLD | lncRNA HULC | MAPK | ↑ | |
NAFLD | lncRNA-Gm9795 | TNF, IL-6, and IL-1 | ↑ | |
NAFLD | lncRNA Platr4 | NF-κB | ↓ | |
Osteoporosis | lncRNA MIAT | miR-150-5p | ↑ | |
Osteoporosis | lncRNA RAD51-AS1 | YBX1 | ↓ | |
Osteoporosis | lncRNA TCONS_00072128 | caspase 8 | ↑ | |
Osteoporosis | lncRNA TUG1 | Hippo | ↓ | |
Osteoporosis | LncDIF | miR-489-3p | ↑ | |
Osteoporosis | LncNEAT1 | Smurf1 | ↓ | |
Osteoporosis | lncRNA LIOCE | Osterix | ↓ | |
Osteoporosis | lncRNA NRON | NFATc1 | ↓ | |
Osteoporosis | lncAK077216 | NIP45 | ↑ |
