Fig. 1
From: RNA methylation into m1A era: a new regulation over T-cell function
TRMT61A-mediated tRNA-m1A58 modification serves as a novel “translation checkpoint” for CD4+ T-cell proliferation. In the stage of early T-cell activation, efficient translation control is activated by TRMT61A/TRMT6-mediated tRNA-m1A58 modification on a subset of early upregulated tRNA to enable synthesis of MYC and of a specific group of key functional proteins, which is required to promote rapid T cell into cell cycles and expansion
