Fig. 1
From: SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
Hospitalization burden and survival curves stratified by IL-18 levels after COVID-19 diagnosis. a Kaplan–Meier curves illustrate significant (P-value = 5.71E−03) overall survival differences stratified by IL-18 tertiles based on time from COVID-19 test to 60-day follow-up (discharge or death). There was worse survival if IL-18 levels were high (red, above cutoffs of 102 pg/mL versus green, 48.6–102 pg/mL versus blue, below cutoffs of 48.6 pg/mL). Each line indicates the predicted survival probability over follow-up time. b Boxplot of IL-18 tertiles and days spent hospitalized is plotted. c IL-18 fluorescence microscopy of human lung from COVID-19 patients vs. non-COVID-19 patients
