Fig. 9
From: SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
Model illustrating the associations between SARS-CoV-2 signaling, mitophagy inhibition, IL-18 activation, and heart injury. Upon infection, Spike protein can inhibit mitophagy and induces mitochondrial ROS production, thus leading to inflammasome activation, IL-18 maturation, and the occurrence of heart injury. The schematic illustration was designed by BioRender
