Fig. 5
From: Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Combination treatments for overcoming the tumor cell plasticity induced-therapy resistance. Tumor cells evade targeted treatments by interacting with TME and via EMT programs. Inflammation, hypoxia, and immunosuppressive TME contribute to therapy evasion, and such induced-resistance could be inhibited by a combination treatment including anti-inflammation and anti-hypoxic drugs and immunosuppressive ICB regimens. EMT-modulating agents, on the other hand, could also deal with plasticity induced-therapy resistance as a combination treatment and lead to tumor cell death. TME tumor microenvironment, EMT epithelial-to-mesenchymal transition, ICB immune checkpoint blockade, Rg3 ginseng-extracted 20(R)-Ginsenoside
