Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Fig. 5

TRP channels in IBD. TRP channels can be stimulated by a variety of factors in the intestinal lumen, including temperature, chemoregulators, and inflammation, and act as auxiliary transducers for GPCR. Interestingly, TLRs play a major role in the regulation of TRPV1 signaling. Stimulation of TRP channels on EC triggers the release of the neuropeptides CGRP and SP, which activate surrounding immune cells and release more inflammatory factors such as TNF-α, IL-1β, histamine, and IFN-γ. These inflammatory factors accumulate at the GPCR of primary afferent sensory neurons. Subsequent activation of TRP channels on neurons triggers the release of neurokinin A, CGRP, and SP, which promote pain perception and inflammatory responses. Created with BioRender.com

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