Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Fig. 6

Effect of TRP channels on NAFLD. HC-067047 (HC) inhibits TRPV4 activity, increases CYP2E1 activity, and upregulates IL-1β, IFN-γ, HMGB1, and MCP-1 expressions, which lead to NAFLD. Activation of TRPV1 increases ATP consumption and cholesterol metabolism, reduces thermogenesis and calcium ion concentrations, decreases ROS levels, visceral fat accumulation, and toxicity and ultimately inhibits NAFLD development. Conversely, inhibition of TRPV1 activity is followed by a decrease in serum glucose and insulin, which can exacerbate the disease. Interestingly, curcumin counteracts the development of NAFLD by inhibiting TRPM2, which results in lower calcium ion concentrations and ROS levels and inhibits hepatocyte damage and death. Created with BioRender.com

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