Table 2 Structures of the TRP channels
Classification | Receptor type | Species | Ligand | Released year | Resolution (Ã…) | PDB ID | Ref. | |
|---|---|---|---|---|---|---|---|---|
TRPC | TRPC3 | Short transient receptor potential channel 3 | Human | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate; (2R)-3-hydroxypropane-1,2-diyl dihexanoate; 2-acetamido-2-deoxy-beta-D-glucopyranose | 2018 | 3.30 | 6CUD | |
TRPC4 | Transient receptor potential cation channel subfamily c member 4a | Zebrafish | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate; 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1 ~ {H}-pyridazin-6-one; Calcium ion | 2020 | 3.80 | 7B05 | ||
TRPC5 | Short transient receptor potential channel 5 | Human | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate; Phosphatidylethanolamine; (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate; Cholesterolhemisuccinate; Zino ion; Calcium ion | 2021 | 3.00 | 7E4T | ||
TRPC6 | Short transient receptor potential channel 6 | Mouse | / | 2018 | 3.80 | 6CV9 | ||
TRPV | TRPV1 | Transient receptor potential cation channel subfamily V member 1 | Rat | / | 2013 | 3.27 | 3J5P | |
[(2 ~ {R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; Sodium ion; Phosphatidylinositol; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol | 2021 | 2.63 | 7LP9 | |||||
Transient receptor potential cation channel subfamily V member 1, Kappa-theraphotoxin-Cg1a 1 | Rat, Chilobrachys guangxiensis | / | 2013 | 3.8 | 3J5Q | |||
TRPV2 | Transient receptor potential cation channel subfamily V member 2 | Rat | / | 2019 | 3.70 | 6U84 | ||
TRPV3 | Transient receptor potential cation channel subfamily V member 3 | Mouse | (2 S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate; Diundecyl phosphatidyl choline | 2020 | 3.30 | 6LGP | ||
TRPV4 | Transient receptor potential cation channel subfamily V member 4 | Human | Phosphate ion; Glycerol | 2012 | 2.85 | 4DX1 | ||
TRPV5 | Transient receptor potential cation channel subfamily V member 5 | Rabbit | / | 2022 | 3.20 | 7T6J | ||
TRPV6 | Transient receptor potential cation channel subfamily V member 6 | Human | / | 2017 | 3.60 | 6BO8 | ||
TRPA1 | Transient receptor potential cation channel subfamily A member 1 | Human | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; [(2 ~ {R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate; N-benzylthioformamide | 2020 | 3.06 | 6PQP | ||
TRPM | TRPM2 | Transient receptor potential cation channel subfamily M member 2 | Human | / | 2018 | 3.60 | 6MIX | |
TRPM3 | Transient receptor potential cation channel, subfamily M, member 3 | Mouse | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE; (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en; Sodium ion | 2022 | 3.20 | 8DDR | ||
TRPM4 | Transient receptor potential cation channel subfamily M member 4 | Mouse | Sodium ion | 2017 | 3.14 | 6BCJ | ||
TRPM5 | Transient receptor potential melastatin 5 | Zebrafish | (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside; (25R)-14beta,17beta-spirost-5-en-3beta-ol; 2-acetamido-2-deoxy-beta-D-glucopyranose | 2021 | 2.80 | 7MBP | ||
TRPM7 | TRPM7 | Mouse | / | 2018 | 4.10 | 6BWF | ||
TRPM8 | Transient receptor potential cation channel subfamily M member 8 | Mouse | Calcium ion | 2022 | 2.88 | 7WRB | ||
TRPN | No mechanoreceptor potential C isoform L | Drosophila melanogaster | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE | 2017 | 3.55 | 5VKQ | ||
TRPP | TRPP2 | Polycystin-2 | Human | 2-acetamido-2-deoxy-beta-D-glucopyranose | 2016 | 3.00 | 5T4D | |
TRPP3 | Polycystic kidney disease 2-like 1 protein | Human | 2-acetamido-2-deoxy-beta-D-glucopyranose | 2018 | 3.38 | 5Z1W | ||
Human | / | 2012 | 2.80 | 4GIF | ||||
TRPML | TRPML1 | Mucolipin-1 | Mouse | Sodium ion | 2022 | 2.60 | 7SQ8 | |
TRPML2 | Mucolipin-2 | Human | 2-(N-MORPHOLINO)-ethanesulfonic acid; Glycerol; Potassium ion; Chloride ion | 2019 | 2.00 | 6HRR | ||
TRPML3 | Mucolipin-3 | Callithrix jacchus | 1,2-Distearoyl-sn-glycerophosphoethanolamine; CHOLESTEROL HEMISUCCINATE; Sodium ion | 2017 | 2.94 | 5W3S | ||
