Table 3 Agonists and inhibitors of TRP channels

TRPA1

Cinnamaldehyde, Sanguinarine, Probenecid, JT010, Methylglyoxal

GDC-0334, HC-030031, Chembridge-5861528, GRC17536, ODM-108, A-967079

Pain, inflammation, asthma, cancer, obesity, cough

³⁸

TRPV1

Capsaicin, Resiniferatoxin, Oxytocin, Rinvanil, Arvanil

SB-705498, AMG517, JNJ17203212, AZD1386

Pain, cough, metabolism, epilepsy

²³⁸

TRPV2

O1821

Tranilast, piperone

Alzheimer’s disease, rheumatoid arthritis, cardiomyopathy

^670,671,672

TRPV3

Carvacrol, camphor, incensole acetate, serratol, menthol,

Coumarin, osthole, verbascoside, pulchranin A, ruthenium red, PC5, lidocaine, 17R-RvD1

Skin disorders, anxiety, convulsions, pain, itch

^673,674

TRPV4

4α-PDD, GSK1016790A, RN-1747

GSK2798745, HC-067047, GSK2193874, PF-05214030

Edema, inflammation

⁶⁷⁵

TRPM8

Menthol, Rotundifolone, Eucalyptol, Cubebol

PF-05105679, Cannabidivarin, AMG-333, SML0893

Vasoconstriction, blood glucose regulation, dry eyes, pain

⁶⁴⁶

TRPM7

Clozapine, Naltriben

Ruthenium red, 2-APB, SKF-96365, Ginsenoside Rg3

Cancer, cardiac fibrosis

⁶⁷⁶

TRPM3

CIM0216, PregS, Nifedipine

Promethazine

Pain, chronic fatigue syndrome

^271,677

TRPM2

NAD, NAADP

8-Br-cADPR, Flufenamic acid, Imidazole anti-fungal agents, 2-APB

Insulin release, cytokine production, endothelial permeability

⁶⁷⁸

TRPC3

GSK1702934A, PLC

1-benzilpiperadine, Pyr3, 2-APB

Hind-limb ischemia, myocardial ischaemia, hypertension, convulsions

^679,680,681

TRPC6

3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one, oxygen-glucose deprivation

SKF96365, Pyrazolo[1,5-a]pyrimidine, larixyl acetate, SH045

Alzheimer’s disease, renal ischemic reperfusion injury, gastric cancer, endothelial dysfunction

^682,683,684

TRPML

MK6-83, ML-SA1

Trans-ML-SI3, ML-SI1, ML-SI3

Glioblastoma, antiviral, schistosomiasis

^685,686,687