Table 4 FDA-approved TRP channel-targeting drugs

From: TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Drug

Function

Target

Drug source

Adverse events

Ref.

Menthol

Antipruritic, analgesic

TRPM8, TRPA1

Natural/chemical synthesis

Increased tobacco smoke toxicity; induced acute respiratory irritation

160

Resiniferatoxin

Control of pain associated with bone cancer in dogs

TRPV1

Chemical synthesis

Lethargy, loss of appetite

688

NGX-4010

Relief of neuralgia after shingles

TRPV1

Dermal patch containing 8% capsaicin

/

689

Eugenol

Sedation

TRPV3, TRPA1

Natural/chemical synthesis

/

690

Back to article page