Table 2 Delivery ligands targeting bone cells or bone marrow
From: Targeting strategies for bone diseases: signaling pathways and clinical studies
Ligand | Targeting feature | Ref |
|---|---|---|
Calcitonin gene-related peptide (CGRP) | CGRP receptor on pOCs | |
Hyaluronic acid (HA) | CD44 on the surface of the osteoclasts and the CD44-rich bone marrow microenvironment | |
cRGDyk | α5β3-integrin on osteoclasts membrane | |
Aptamer CH6 | Osteoblasts | |
SDSSD | Osteoblast-specific factor 2 (OSF-2) | |
LLP2A | Binding integrin α4β1 to improve homing | |
CXCR4 or CXCR7 | Binding CXCL12 to promote homing to bone marrow | |
SKPPGTSS (SKP) | Possessing a partial amino acid sequence homology with a region of CD84 to promote homing | |
VTAMEPGQ (VQ) | Rat mesenchymal stem cells specific | |
EPLQLKM (E7) | Efficiently interact specifically with MSCs without any species specificity |
