Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme

Fig. 1

Formation and characterization of BSA-Cu SAN. a Schematic illustration of the synthesis of BSA-Cu SAN and its function of destroying pathogen-tumor symbionts for antitumor therapy. b Negative-stain electron microscopy image of BSA-Cu SAN. White bots represent BSA-Cu SAN, some of which are marked by yellow arrows. Minority of agglomerates circle in yellow. c Atomic HAADF image of BSA-Cu SAN with SAED pattern inset in the bottom left corner and partial single Cu atoms highlighted in yellow dash circles. d The intensity spectrum image along the distance in the yellow dash tangle in (c). e Pseudo-color image of corresponding intensity of (c), scale bars = 2 nm. f the enlarged image of (e). g Elemental mapping of BSA-Cu SAN. h Cu 2p XPS spectra of BSA-Cu SAN. i Binding site of Cu+ on BSA based on the highest docking score. j Protein-ligand interaction diagram for Cu+

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