Table 1 Functions of Piezo channels in cellular mechanotransduction
From: Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Type | Target | Mechanical stimulation | Mechanism | Reference |
|---|---|---|---|---|
Piezo1 | Vascular endothelium development | Shear stress | Ca2+influx→MTP-MMP signaling→focal adhesion and endothelial cell sprout formation; | |
Vascular tone | Shear stress | Ca2+influx→G-coupled endothelial adrenomedullin receptor→cAMP→ eNOS→NO; Ca2+influx→ATP→PI3K/AKT→eNOS→NO | ||
Vascular remodeling | Stretch | Ca2+influx→transglutaminase →ECM remodeling | ||
Erythrocytes | Shear stress | Ca2+influx→K+ efflux→red blood cells dehydration | ||
Erythrocytes | Shear stress | Ca2+influx→pannexin-1→ATP release | ||
Nervous system | Traction force | Ca2+influx→neural differentiation →neuron-astrocyte interaction | ||
Gastric mucosa | Antrum distension | Activated G cells→gastrin secretion | ||
Lung endothelium | Shear stress | Ca2+influx→calpain→Src cleavage→stabilization of adherens junctions | ||
Lung endothelium | Hydrostatic pressure | Ca2+influx→calpain→disruption of adherens junctions | ||
Aoveoli | Stretch | Ca2+influx→Bcl-2 pathway→type II epithelial cells apoptosis | ||
Urinary bladder | Stretch | Ca2+influx→ATP→attenuate storage disorders | ||
Tumor | ECM stiffness | YAP-Piezo1→proliferation; Ca2+influx→AKT/mTOR phosphorylation→proliferation; Piezo1–mitochondrial calcium uniporter–HIF-1α–VEGF axis→metastasis | ||
Piezo2 | Gastrointestinal epithelium | Mucosal force | 5-HT pathway→mucosal secretion | |
Airway | Stretch | Ablation of Piezo2→Airway-innervating sensory neurons→ respiratory distress and death in newborn mice | ||
Urinary bladder | Stretch | Sensory neuron→bladder filling sensation | ||
Piezo1/2 | Baroreceptor reflex | Shear stress | Elevated blood pressure→Piezo1/2 →nodose-petrosal-jugular-ganglion complex→ decreased blood pressure and heart rate | |
Chondrocyte anabolic and biosynthesis | Mechanical stress | GsMTx4→Piezo1/2 inhibition→ alleviate chondrocyte injury |
