Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

Fig. 2

The sphingolipids metabolism pathway. Sphingomyelin on the plasma membrane can be converted to ceramide by sphingomyelinase. Ceramide can also be synthesized de novo from palmitoyl CoA and Serine or synthesized from sphingosine by ceramide synthase. SM Sphingomyelin, Cer ceramide, So Sphingosine, S1P Sphingosine 1-phosphate, HDAL Hexadecenal, PE Phosphorylethanolamine, dhCer dihydroceramide, Sa Sphinganine, KDS 3-ketodihydrosphingosine, P-CoA Palmitoyl-CoA, ASM Acid sphingomyelinase, SMS Sphingomyelin synthase, CDase Ceramidase, CerS Ceramide synthase, SPP S1P phosphatase, SPHK Sphingosine kinase, S1PL S1P lyase, DES dihydroceramide Δ4-saturase, KDSR 3-ketodihydroshpingosine reductase, SPT Serine palmitoyltransferase

Back to article page