Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

Fig. 5

Arachidonic acid metabolism. The arachidonic metabolism pathway includes three branches: 1. CYP enzymes convert arachidonic acids to ETTs or HETEs. 2. 5-lipoxygenase catalyzes arachidonic acids to lipoxins and leukotrienes 3. The COX-1/COX-2 pathway that produces prostaglandins. AA arachidonic acids, PGG2 prostaglandin G2, PGH2 prostaglandin H2, TXA2 thromboxane A2, PGE2 prostaglandin E2, PGI2 prostaglandin I2, PGD2 prostaglandin D2, PGF2α prostaglandin F2α, 5-HPETE 5-hydroperoxyeicosatetraenoic acid, LXB4 lipoxin B4, LXA4 lipoxin A4, LTA4 leukotriene A4, LTB4 leukotriene B4, LTC4 leukotriene C4, LTD4 leukotriene D4, LTE4 leukotriene E4, ETTs epoxyeicosatrienoic acids, HETEs hydroxyeicosatetraenoic acids, DiHPAs dihydroxydocosapentaenoic acids, DHEQs dihydroxyeicosatetraenoic acids, DHETs dihydroxyeicosatrienoic acids, PLA2 Phospholipase A2, COX-2 cycloxygenase-2, COX-1 cycloxygenase-1, 5-LOX 5-Lipoxygenase, 12-LOX 12-Lipoxygenase, LTC4S LTC4 synthase, LTA4H LTA4 hydrolase, TXAS Thromboxane A synthase, PEG2I PEG2 isomerase, PGIS prostaglandin I synthase, PGD2 I PGD2 isomerase, PGF2αR PGF2α reductase, CYP cytochrome P450, sEH soluble epoxide hydrolase

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