Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting

Fig. 3

Spatiotemporal effects of STF on the metabolome in multiple brain regions. a Three-dimensional diagrams of PLS-DA of metabolic responses to different periods of STF in SC, R2X = 0.478, R2Y = 0.585, Q2 = 0.160; OB, R2X = 0.508, R2Y = 0.543, Q2 = 0.203; HIP, R2X = 0.497, R2Y = 0.603, Q2 = 0.0753; CBL, R2X = 0.426, R2Y = 0.562, Q2 = −0.0154; COR, R2X = 0.472, R2Y = 0.539, Q2 = 0.129; HYT, R2X = 0.522, R2Y = 0.497, Q2 = −0.00197 and BST, R2X = 0.472, R2Y = 0.522, Q2 = 0.0736. b Number of DEMs upon STF in seven brain regions. c Number of DEMs after various periods of STF in seven brain regions. Venn diagram of the number of DEMs (GC-MS data only) after STF in (d) BST and SC, (e) COR and HIP. Venn diagrams were generated using online tools (https://jvenn.toulouse.inrae.fr/app/example.html). More metabolites were found to be changed after STF in SC and HIP, compared with BST and COR, respectively. Heat maps of the DEMs (GC-MS data only) upon STF in (f) BST and SC, (g) COR and HIP

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