Table 1 Hedgehog signaling pathway target genes

Ptch1⁸⁴

Patched 1

Receptor that initiates signaling pathways, negative feedback regulation

Ptch2⁸⁴

Patched 2

Receptor that initiates signaling pathways

Gli1⁸⁴

Glioma-associated oncogene 1

Direct transcriptional activator, positive feedback regulation

Bmi1⁸⁵

Bmi1 proto-oncogene

Transcriptional repressor regulating the proliferative capacity of cells

Myc⁸⁶

Myc proto-oncogene

Cell cycle progression, apoptosis and cellular transformation

CycD and CycE⁸⁷

CyclinD and CyclinE

Cell cycle progression

Fgf4⁸⁹

Fibroblast growth factor 4

Involved in varieties of biological processes including embryonic development, cell growth, morphogenesis, tissue repair and invasion

Hhip⁸⁸

Hedgehog interacting protein

Involved in varieties of developmental processes including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development

Nkx6.1⁹⁰

NK6 homeobox 1

Required for the development of beta cells

Nkx2.2⁹⁰

NK2 homeobox 2

Involved in the morphogenesis of the central nervous system

Olig2⁹⁰

Oligodendrocyte transcription factor 2

Regulator of ventral neuroectodermal progenitor cell fate

FoxA2⁹⁰

Forkhead box A2

Transcriptional activators that regulate the specificity and differentiation of dopaminergic neurons

Snai1⁹¹

Snail family transcriptional repressor 1

Critical for mesoderm formation in the developing embryo

Zeb1⁹¹

Zinc finger E-box binding homeobox 1

Associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy

Twist2⁹¹

Twist family bHLH transcription factor 2

Inhibitors of osteoblast maturation, maintaining the pre-osteoblast phenotype of cells during osteoblast development

Foxc2⁹¹

Forkhead box C2

Involved in the development of mesenchymal tissues

Pax6, Pax7 and Pax9⁹⁷

Paired box 6, 7 and 9

Involved in the development of neural tissues