Table 2 Approved drugs targeting amino acid metabolism
Name | Research and development code | Target | Disease | Status |
|---|---|---|---|---|
Sodium phenylbutyrate | ACER-001 | Branched Chain Keto Acid Dehydrogenase Kinase (BCKDK) | Maple glycosuria; Disturbance of urea cycle | Approved |
Pegaspargase | NSC-109229 | Asparaginase | Acute lymphoblastic leukemia; Acute B lymphoblastic leukemia | Approved |
Crisantaspase | OP-01 | Asparaginase | Acute lymphoblastic leukemia | Approved |
Calaspargase pegol | EZN-2285 | Asparaginase | Acute lymphoblastic leukemia; Ductal adenocarcinoma of pancreas | Approved |
Crisantaspase | JZP-458 | Asparaginase | Acute lymphoblastic leukemia; Lymphocytic leukemia | Approved |
Asparaginase | Â | Asparaginase | Acute lymphoblastic leukemia | Approved |
Arginine pidolate | G-278 | Â | Cognitive impairment | Approved |
