Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

Fig. 1

Overview of the regulatory mechanisms of ER stress in ocular diseases. ER stress plays an important role in several ocular diseases, including glaucoma, diabetic retinopathy, age-related macular dystrophy (AMD), retinitis pigmentosa (RP), achromatopsia (ACHM), cataract, corneal diseases, DES, myopia, uveitis, and uveal melanoma. The concrete mechanisms of ER stress in ocular diseases include regulation of gene mutations, epigenic modifications, impaired autophagy, oxidative stress, mitochondria dysfunction, and metabolism. The figure was created with BioRender.com (https://www.biorender.com/). AMD age-related macular dystrophy, RP retinitis pigmentosa, ACHM achromatopsia, DES dry eye syndrome

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