Fig. 11

Exposure to Chronic Unpredictable Stress (CUMS) induces morphological atrophy in prefrontal cortex astrocytes in mice. a Representative 3D reconstruction of astrocyte in control and CUMS groups. b Sholl analysis of astrocytic morphology for control and CUMS groups shows the number of intersections of astrocytic branches with concentric spheres centred in the middle of cell soma. c Maximal number of intersections for astrocytes in control and CUMS groups. d Average length of astrocytic processes in control and CUMS groups. b–d n = 15 for each group. e Representative examples of astrocytic territorial domains obtained as a projection of astrocytes along the z-axis projection for control and CUMS animals. f Average astrocytic domain area (E) and average length of astrocytic processes for control and CUMS group. All data are presented as mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001. The number of experiments is indicated on each column. Reproduced from ref. ⁴⁰⁹