Fig. 5
From: SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals
Vaccine-elicited TFH cell responses to Omicron subvariants. a Frequencies of vaccine-elicited spike-specific TFH cell, CXCR3+ TFH cell, and CXCR3− TFH cell responses upon BSA, prototype, BA.1, or BA.4/5 spike protein stimulation (n = 17). b Comparison of spike-specific TFH cell, CXCR3+ TFH cell, and CXCR3− TFH cell responses (data presented with background subtracted; responses below background are shown as 0.001%) upon prototype, BA.1, or BA.4/5 spike protein stimulation (n = 17). Data are presented as the mean ± SEM. c Percentage of spike-specific TFH cell, spike-specific CXCR3+ TFH cell, and CXCR3− TFH cell responders (stimulation index > 2 was considered to be a positive response) upon prototype, BA.1, or BA.4/5 spike protein stimulation (n = 17). For (a, b), paired t-test was used to analyze the differences between the two groups, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. P < 0.05 was considered to be a two-tailed significant difference, ns, not significant
