Fig. 4
From: γδ T cells: origin and fate, subsets, diseases and immunotherapy
An inverted Vδ1/Vδ2 ratio in the peripheral blood of various solid tumor patients, including those with liver, lung, breast, pancreatic, kidney, and other types of cancer. a In healthy populations, the Vδ1/Vδ2 ratio is usually less than 1. However, in cancer patients, including those with hepatocellular carcinoma (HCC), this ratio is reversed, and it becomes far greater than 1 according to our previous work.243,748 b A hypothetic sketch suggests that the normal Vδ1/Vδ2 ratio is skewed by the burden of transformation and the challenges posed by the tumor microenvironment (TME), resulting in a disordered ratio. Available therapy approaches provide alternatives for re-modulating the TME to achieve the normalization of the Vδ1/Vδ2 ratio and subsequently immune function
