Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

Fig. 1

Development and characterization of Fe65-engineered exosomes. a Schematic diagram showing the steps involved in the production of engineered Fe65-EXO. Representative b, c immunofluorescence images showing expression of Fe65, d protein level of Fe65 in control- and Fe65 OE- HT22 hippocampus neuron cells. Representative e–g size distribution, h–j, k–m CD63-, and Fe65-positive immunogold dots, and their relative quantification, n, o protein level of Fe65 by n WB, and o dot-blot, and p zeta potential of exosomes isolated from control- and Fe65 OE- HT22 hippocampus neuron cells. In g, j, m, and p data are shown as mean ± standard error mean (SEM). Statistical analysis was performed by Student’s t-test to compare Control-EXO vs. Fe65-EXO. Significance level: **P < 0.01, NS not significant

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