Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

Fig. 2

Higher autologous uptake of Fe65-engineered exosomes by APP overexpressed hippocampus neuron cells. a–h Enhanced autologous uptake of Fe65-EXO by APP OE-HT22 cells compared with HT22 cells, and i–p enhanced heterologous uptake of Fe65-EXO by APP OE-N2a cells compared with N2a cells after 24 h. Nuclei: DAPI (blue), cell membrane: APP (red), Fe65-EXO: Green (green). EXO-APP (yellow). In a–p; scale bar = 10 µm. q, r Effect of Fe65-EXO on the viability of HT22- and N2a- neuron cells, respectively. HT22- and N2a- neuron cells were treated with cell culture medium (control), control EXO, or Fe65-EXO for 24 h, followed by the measurement of viability using MTT assay protocol. In q and r, data are shown as mean ± S.E.M (N = 6). Statistical analysis was performed by one-way ANOVA for multiple comparison of Vehicle Control vs. Control EXO or Fe65-EXO, Significance level: **P < 0.01, NS not significant

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