Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

Fig. 4

Biodistribution of Fe65-EXO-Cory-B in the brain of AD mouse. Intravenously injected a control exosomes, b Fe65-EXO, c Cory-B, and d Fe65-EXO-Cory-B in 5xFAD mouse model. e Intraperitoneally injected Fe65-EXO-Cory-B in 5xFAD mouse model. The exosomes are labeled with Exo-Glow dye, and after its administration, AD mice were imaged at various times using the IVIS In Vivo Imaging System. f–j The quantitative time course bar graphs show the biodistribution of control-EXO, Fe65-EXO, Cory-B, and Fe65-EXO-Cory-B (i.v. or i.p.) in the brain of a 5xFAD mouse model. k–o Immunofluorescence staining showing colocalization of APP (shown in red) and exosomes (labeled with Exo-Green; shown in green) in the hippocampus region of brain of 5xFAD mouse model treated with control-EXO, Fe65-EXO, Cory-B, and Fe65-EXO-Cory-B (i.v. or i.p.), and p–t the corresponding fluorescence intensity of APP and Exo-Green, depicting the strength of their colocalization. In k–o, scale bar = 25 µm

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