Fig. 5
From: Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Enhanced antitumor activities against untreated distant MC38 tumors. a Mice were subcutaneously inoculated with MC38 tumor cells in both flanks. After establishment of tumors, the right tumor was intratumorally injected with PBS, Ad, OAd-null, or OAd-SIRPα-Fc (1 × 108 pfu per tumor) on days 1, 4, 7, 10, and 13. b Growth of injected tumors and distant tumors in the bilateral MC38 tumor model (n = 10). Data are represented as mean ± SEM. c, d TILs in injected tumors (c) and distant tumors (d) were analyzed by flow cytometry (n = 3). Data are represented as mean ± SD. (*p < 0.05, **p < 0.01, ***p < 0.001)
