Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Fig. 3

Interdependent BCMA–nanobody multimerization in solution. a Analysis of the molecular masses of the BCMAECD, nanobodies, and NbT in solution using sedimentation velocity analytical ultracentrifugation (SV-AUC). The derived molecular weights are indicated for the corresponding peaks. Cartoon illustrations reflect our interpretation of the stoichiometries. b Molecular masses of the BCMAECD complexes assayed by SV-AUC. Excess BCMAECD was used to form the nanobody complexes

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