Fig. 3
From: Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer
The crucial role of G6PD ubiquitination in the tumorigenesis of HER2-positive breast cancer. a Fluorescence images of SK-BR-3 cells subjected to G6PD overexpression for the detection of autophagy. b, c RT-qPCR (b) and western blot (c) analysis of relative G6PD mRNA expression in different treatment groups (n = 3). d The GEPIA database analysis of the G6PD expression level in the TCGA database and in the tumor tissues. e The GEPIA database analysis of the G6PD expression in TCGA samples with different tumor stages. f TCGA database analysis of the association between G6PD level and the breast cancer prognosis by the Kaplan–Meier plotter. g The GEPIA database analysis of the expression level of G6PD in the TCGA database. h Correlation analysis between G6PD expression levels and the prognosis of patients with acute myeloid leukemia, brain lower-grade glioma, liver hepatocellular carcinoma, and mesothelioma. All bar values are represented as mean ± SD. *P < 0.05, **P < 0.01
