Table 2 Chemical structures of representative small-molecule PCSK9 inhibitors, natural small molecules with PCSK9 inhibitory potential, and peptidomimetic PCSK9 inhibitors
From: Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside
Inhibitor type | Name | Structure | Reference |
|---|---|---|---|
Small-molecule PCSK9 inhibitor | 3 f |
| |
7030B-C5 |
| ||
BRD8518 |
| ||
Carboxylic acid 9 |
| ||
CVI-LM001 |
| ||
DC371739 |
| ||
DFDIM |
| ||
PF-06446846 |
| ||
PF-06815345 |
| ||
Natural small molecules with PCSK9 inhibitory potential | 5a,6a-epoxy-(22E,24 R)-ergosta-8(14),22-diene-3b,7b-diol |
| |
(2 R,3 R)-3,7,2’-trihydroxy-5-mathoxy-flavanone |
| ||
Adenosine |
| ||
Berberine |
| ||
Curcumin |
| ||
Dihydrocucurbitacin B |
| ||
Erybraedin D |
| ||
Hanabiratakelide A |
| ||
Manglisin E |
| ||
Moracin C |
| ||
Naringin |
| ||
Neolignan |
| ||
Norsesquiterpene |
| ||
Pinostrobin |
| ||
Polydatin |
| ||
Pseurotin A |
| ||
Quercelin-3-glucoside |
| ||
Schisandrin C |
| ||
Schisandrol B |
| ||
Skullcapflavone II |
| ||
Sparoside A |
| ||
Tanshinone IIA |
| ||
Vitamin C |
| ||
Peptidomimetic PCSK9 inhibitors | 13PCSK9i |
| |
Cyclic-tetramer C12 |
| ||
LDLL-1dinr |
| ||
MeIm |
| ||
MK-0616 |
| ||
tetra-P9-38 |
|
