Fig. 2
From: Intratumoural microbiota: a new frontier in cancer development and therapy
The potential origins of intratumoural microbiota. a Mucosal barrier invasion. Microorganisms may invade the tumour through the damaged mucosa. b Adjacent tissue invasion. the microbiome community between the tumour and adjacent normal tissue share many similarities. c Hematogenic invasion. microorganisms from the oral cavity, intestine, and other potential locations may be carried to the tumour locations and colonise the tumour through destroyed blood vessels. d Attraction of tumour specific microenvironment. immunosuppressive, hypoxic, and metabolic nutrient-enriched environments in tumours may enhance microbial colonisation. Created with BioRender.com
