Table 2 Prognostic role of intratumoural microbiota
From: Intratumoural microbiota: a new frontier in cancer development and therapy
Cancer types | Pathological type | Stage | Treatment | Microorganism | Outcomes | Survival |
|---|---|---|---|---|---|---|
Oesophageal cancer | Squamous cell carcinoma, adenocarcinoma, and others | — | Neoadjuvant chemotherapy/ chemoradiotherapy, surgery | Species Fusobacterium nucleatum253 | Risk factor | OS |
Squamous cell carcinoma | All stages | Neoadjuvant chemotherapy/ chemoradiotherapy, surgery | Species Fusobacterium nucleatum269 | Risk factor | PFS | |
Lung cancer | Non-small cell lung cancer | Stage II | Surgery | Order Actinomycetales, order Pseudomonadales261 | Risk factor | DFS |
Non-small cell lung cancer | Stage III, IV | Surgery/ biopsy, targeted therapy/ chemotherapy | Speices Haemophilus parainfluenzae262 | Risk factor | OS | |
Species Serratia marcescens, species Acinetobacter jungii, species Streptococcus constellation262 | Protective factor | OS | ||||
Non-small cell lung cancer | All stages | — | Genus Thermus, Genus Legionella263 | Risk factor | — | |
Non-small cell lung cancer | Stage IIIB, IV | Chemotherapy, immunotherapy | Species Helicobacter pylori274 | Risk factor | OS, PFS | |
Liver cancer | Hepatocellular carcinoma, intrahepatic cholangiocarcinoma, combined HCC and iCCA | — | Surgery | Family Pseudomonadaceae54 | Protective factor | OS |
Colorectal cancer | — | All stages | Surgery | Species Fusobacterium nucleatum254 | Risk factor | OS |
— | All stages | Surgery | Genus Fusobacterium, genus Granulicatella, genus Gemella260 | Protective factor | DFS | |
— | All stages | Biopsy | Species Porphyromonas gingivalis265 | Risk factor | OS | |
— | Stage IV | — | Genus Candida11 | Protective factor | — | |
Genus Saccharomyces11 | Risk factor | — | ||||
Gastric Cancer | — | All stages | Surgery | Species Fusobacterium nucleatum255 | Risk factor | OS |
— | All stages | Surgery, chemotherapy | Species Helicobacter pylori270 | Protective factor | OS | |
— | — | Surgery | Species Helicobacter pylori271 | Protective factor | OS | |
— | Stage II, III | Surgery, chemotherapy | Species Helicobacter pylori272 | Protective factor | OS, DFS | |
Adenocarcinoma, squamous carcinoma, carcinoid carcinoma | Stage III, IV | Immunotherapy | Species Helicobacter pylori275 | Risk factor | PFS | |
Pancreatic cancer | Pancreatic ductal adenocarcinoma | All stages | Surgery, chemotherapy | Genus Fusobacterium257 | Risk factor | OS |
Pancreatic ductal adenocarcinoma | Stage I, II | Surgery, neoadjuvant chemoradiotherapy | Genus Pseudoxanthomonas, genus Streptomyces, genus Saccharopolyspora, genus Bacillus clausii264 | Protective factor | OS | |
Melanoma | — | — | Immunotherapy | Genus Clostridium7 | Protective factor | — |
Species Gardnerella vaginalis7 | Risk factor | — | ||||
— | Stage III, IV | Immunotherapy | Species Helicobacter pylori273 | Risk factor | OS | |
— | — | Immunotherapy | Genus Cladosporium12 | Risk factor | — | |
Oral cancer | Oral squamous cell carcinoma | All stages | Surgery | Species Fusobacterium nucleatum258 | Protective factor | OS |
Anal Squamous Cell Carcinoma | — | All stages | Radiotherapy/chemoradiotherapy, surgery | Species Fusobacterium nucleatum259 | Protective factor | OS |
Vulvar squamous cell carcinoma | — | Stage I, II, and III | Surgery, chemotherapy/ radiotherapy | Species Fusobacterium nucleatum, species Pseudomonas aeruginosa256 | Risk factor | PFS |
Ovarian cancer | — | — | Surgery | Genus Phaeosphaeriaceae12 | Risk factor | PFS |
Kidney cancer | — | — | — | Human endogenous retrovirus118 | Risk factor | OS |
