Table 2 Surgical outcomes

From: Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

Postoperative evaluation

A1 (n = 12)

A2 (n = 12)

B1 (n = 16)

B2 (n = 12)

Patients with definitive surgery—no. (%)

11 (91.7)

10 (83.3)

14 (87.5)

11 (91.6)

Time from last neoadjuvant dose to definitive surgery—week, Median (IQR)

4 (4–6)

5 (4.8–5.3)

5 (4–5)

5 (4–5)

Patients with canceled definitive surgery—no. (%)

1 (8.3)

2 (16.7)

2 (12.5)

1 (8.3)

 Disease progression

1 (100)

1 (50.0)

0 (0)

1 (100)

 Adverse event

0 (0)

1 (50.0)

1 (50.0)

0 (0)

 Other

0 (0)

0 (0)

1 (50.0)

0 (0)

Of patients with delayed surgery, proportion no. (%) with delay of ≤ 2 weeks

3 (27.2)

0 (0)

1 (7.1)

1 (9.1)

Surgical approach—no. (%)

    

 Thoracotomy

0 (0)

0 (0)

0 (0)

0 (0)

 Minimally invasive

11 (100)

9 (90.0)

13 (92.9)

11 (100)

 Minimally invasive to thoracotomy

0 (0)

1 (10.0)

1 (7.1)

0 (0)

Type of resection

    

 Lobectomy

10 (90.9)

6 (60.0)

12 (85.7)

11 (100)

 Pneumonectomy

0 (0)

1 (10.0)

1 (7.1)

0 (0)

 Other

1 (9.1)

3 (30.0)

1 (7.1)

0 (0)

Completeness of resection—no. (%)

    

 R0

10 (90.9)

10 (100)

14 (100)

11 (100)

 R1

1 (9.1)

0 (0)

0 (0)

0 (0)

Median length of hospital stay—days (IQR)

9 (6–17)

10 (8–12)

8 (7–10)

8 (8–10)

Pathological lymph node evaluation

    

 N0

4 (36.4)

6 (60.0)

8 (57.1)

11 (100)

 N1

1 (9.1)

3 (30.0)

5 (35.7)

0 (0)

 N2

5 (45.4)

1 (10.0)

1 (7.1)

0 (0)

 N3

1 (9.1)

0 (0)

0 (0)

0 (0)

Pathological lymph node downstage

    

 Yes

4 (36.4)

7 (70.0)

6 (54.5)

9 (100.0)

 No

7 (63.6)

3 (30.0)

5 (45.5)

0 (0)