Fig. 5
From: Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity
Prediction of binding and affinity identification between the aptamers and the N proteins of SARS, MERS and -OC43. a Prediction of the binding affinity between the aptamers and N proteins of SARS, MERS and HCoV-OC43 via Zdock score. The N protein of SARS-CoV-2 and ALB protein were used as positive and negative control, respectively. The characterizations of affinity and specificity between aptamers and N proteins of (b) SARS, (c) MERS and (d) -OC43 were performed via CE. e The results of molecular docking to predict and simulate the binding sites of aptamer Seq-1022 to N proteins of SARS, MERS and -OC43 using Discovery Studio software
