Fig. 3
From: Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
Mechanistic exploration of 14a and 14b harboring excellent anticoronaviral effects. a 14a and 14b have no inhibitory activity on VSV-G protein-mediated entry. b Representative pictures of SARS-CoV-2 S protein-mediated cell-cell fusion experiments. c Inhibitory curve of compounds against SARS-CoV-2 S protein-mediated cell-cell fusion. d, e Compounds lost most inhibitory activity 5 h after infection in Huh-7 and 293T/ACE2 cells, respectively. f Scheme of time-of-addition experiments for Fig. 3g. g Compounds inhibit viral entry, but not post-viral entry stage. Data are represented as mean ± SEM
