Fig. 10 | Signal Transduction and Targeted Therapy

Fig. 10

From: Protein lipidation in health and disease: molecular basis, physiological function and pathological implication

Fig. 10

Glycosylphosphatidylinositol anchor proteins (GPI-APs) play a role in several cellular signal transduction pathways. In this section, we describe several classical GPI-APs and their roles in cellular signal transduction. CD109 negatively regulates TGF‐β signalling, while it can activate the Jak-STAT3 pathway to drive tumour metastasis. CD14 can activate TLR4 to trigger signalling pathways, including INF, tnf-α and IL-6 signalling, to initiate the immune response. Folate binds to FOLR1 to activate MEK/ERK signalling and the Jak-STAT3 pathway. ART could trigger NAD + -induced cell death. uPAR binds to Upa to stimulate the association of EGFR and β1 integrin to activate MEK/ERK signalling. ER endoplasmic reticulum

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