Fig. 9 | Signal Transduction and Targeted Therapy

Fig. 9

From: Protein lipidation in health and disease: molecular basis, physiological function and pathological implication

Fig. 9

Biosynthesis and maturation of GPI-anchored proteins (GPI-APs). N Nascent proteins first translocate to the ER following the N-terminal signal. After arriving at the ER, the N-terminal signal is removed. Subsequently, GPI-T recognises the amino acid at the ω position and catalyses the attachment of GPI at the ω position, followed by fatty acid remodelling of GPI with or without GalNAc side chain modification of the ER and Golgi. Finally, mature GPI-APs are trafficked to the plasma membrane and associate with raft microdomains. ER endoplasmic reticulum

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