Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

Fig. 6

MEX3A/circMPP6-PDE5A axis is clinically correlated with CRC outcomes. a Western blotting of MEX3A and PDE5A protein expression and qRT-PCR analysis of circMPP6 RNA expression in 8 pairs of matched CRC tumor (T) and adjacent noncancerous tissues (N). GAPDH was used as the loading control. b Representative RNA-FISH and immunofluorescence staining images of circMPP6 and PDE5A in two CRC tissues with high (the first row) or low MEX3A expression (the second row). Nuclei were stained with DAPI (blue). Scale bar, 100 μm. c Representative IHC images of MEX3A and PDE5A protein staining in CRC tissue microarrays from SYSUCC. Scale bar, 100 μm. d Kaplan-Meier analysis of OS for CRC patients from SYSUCC cohorts (n = 88) indicating that high MEX3A and low PDE5A were associated with a poor prognosis. The P value was determined by a Log-rank test. e A proposed model demonstrating that the MEX3A/circMPP6 complex inhibits CRC cell autophagy by mediating PBs-dependent PDE5A mRNA decay

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