Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Anti-lymphangiogenesis for boosting drug accumulation in tumors

Fig. 1

Schematic illustration of the intratumoral accumulation of therapeutic drugs after anti-tumor lymphangiogenesis. With cancer progression, lymphangiogenesis and lymphatic enlargement occur in and around the primary tumor. These processes not only diminish the intratumoral accumulation of therapeutic drugs but also facilitate metastasis. By inhibiting lymphangiogenesis, increased amounts of drugs can be trapped in the tumor tissue, and lymphatic metastasis is reduced

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