Fig. 5
From: Anti-lymphangiogenesis for boosting drug accumulation in tumors
Improved therapeutic efficacies of Dox and Lip-Dox (equivalent Dox dosage: 3 mg/kg) when combined with anlotinib (1.5 mg/kg) in murine 4T1-luc and CT26 xenograft tumor models. a Experimental timeline for treatments in the 4T1-luc tumor model. b Tumor growth curves of the 4T1-luc tumor model (n = 5). c Representative images of H&E staining and TUNEL assay of tumor tissues from different treated groups. Scale bar, 40 μm. d Experimental timeline for treatments in the CT26 tumor model. e Tumor growth curves of the CT26 tumor model (n = 7). f Histological studies with H&E staining and TUNEL assay in CT26 tumor sections. Scale bars, 40 μm. Data are shown as the mean ± s.d. *p < 0.05; **p < 0.01; ***p < 0.001
