Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Fig. 5

Cx3cr1+Ccr2+ Mo-macs in the late stage of the developmental trajectory highly expressed S100 family protein genes. a Volcano plot comparing DEGs for Cx3cr1+Ccr2+ Mo-macs. b Feature plots showing the top 20 DE genes. c KEGG pathway enrichment analysis of upregulated DE genes in Cx3cr1+Ccr2+ Mo-macs. d Dot plot presenting the expression strength of key KEGG pathway genes among Cx3cr1+Ccr2+, Cx3cr1-Ccr2-and Ccr2+ Mo-macs and Kupffer cells. e Violin plots displaying the expression levels of polarization state marker genes and S100a family protein genes. f Volcano plot comparing DEGs between M06 and M09. g Heatmap displaying the expression of selected marker genes in Mo-macs arranged along the pseudotime trajectory. h Scatter plots and fitting curves presenting the expression trend of S100a4, S100a6, S100a10 and S100a11

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